Gut Check: Low-Calorie Sweeteners and the Gut Microbiome
We’re back again with another edition of Gut Check, our series on the relationship between food and the gut microbiome. So far, we’ve taken a closer look at how whole grains, fiber, and fermented foods affect our gut microbes. In this article we’re taking a closer look at low-calorie sweeteners (LCSs) and the growing body of research on their connection to our microbial communities. LCSs (sometimes referred to as non-nutritive sweeteners, high-intensity sweeteners, artificial sweeteners or sugar substitutes) provide sweetness without adding a significant amount of calories. They have a long history of safe use in a variety of foods and beverages, ranging from soft drinks to candy to tabletop sweeteners. In the U.S., the most common LCSs are acesulfame potassium (ace-K), aspartame, monk fruit, saccharin, stevia and sucralose. LCSs are some of the most studied and reviewed ingredients in the world today. And yet, research on their relationship to the gut microbiome is very much in its infancy. Most LCSs are not metabolized by our digestive enzymes, so they travel through the digestive system intact and pass out of the body unchanged. Because of this, scientists have long thought they have no effects on the body. However, recent research has revealed that some LCSs may influence the bacteria in our gut. Most of these studies have been done in animal models and have shown wide-ranging results—from reductions in total bacterial count to increases in short-chain fatty acids, which are made by gut bacteria and are thought to be beneficial for gut health. The translation of these results to humans can be tricky and, in many cases, it’s just plain impractical. A primary reason? Lab animals are often genetically identical to each other and live their lives in the same environments, while in humans the microbiome is reflective of widely […]
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